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. 2022 Jan 30;13(5):1449–1467. doi: 10.1016/j.jcmgh.2022.01.018

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The therapeutic potential of STAT6 inhibition in EoE. (A) IHC staining for phosphorylated STAT6 was performed, with representative images shown. Scale bars: 100 μm. (B) The positive rate of phosphorylated STAT6 in esophageal epithelium are compared. The data are shown as means ± SD (n = 5). (C) Relative expression of CD73 gene in EPC2-hTERT organoids treated with STAT6 inhibitor (AS151749, 400 nmol/L), IL4 (10 ng/mL), or IL13 (10 ng/mL). (D) The frequencies of CD73⁺CD104⁺ cells in organoids treated with AS151749 or dimethyl sulfoxide (DMSO) under the presence of Th2 cytokines. STAT6 silencing efficiency was evaluated by (E) qRT-PCR and (F) Western blot. (G) CD73 gene expression in EPC2-hTERT organoids treated with STAT6 siRNA or nonsilencing (scramble) siRNA with or without IL13. The data are shown as means ± SD (n = 3). Analysis of variance was performed with multiple comparisons. ∗∗P < .01, ∗∗∗∗P < .0001.