Table 4.
Candidate maternal genes for CHDs identified in genome-wide, gene-level analyses
| Analysis | Genea | Filter | Variants | Bonferroni thresholdb | Meta-p |
p values for contributing datasets |
|||
|---|---|---|---|---|---|---|---|---|---|
|
CTD |
LVOTD |
||||||||
| CHOP | PCGC | CHOP | PCGC | ||||||
| LVOTD | GABRB3 | CADD10 | common + rare | <2.7 × 10−6 | 4.0 × 10−6 | – | – | 4.0 × 10−3 | 1.1 × 10−4 |
| common | <3.4 × 10−6 | 6.5 × 10−6 | – | – | 4.0 × 10−3 | 4.0 × 10−4 | |||
| LVOTD | SORCS3 | unfiltered | common + rare | <2.6 × 10−6 | 4.8 × 10−7 | – | – | 6.0 × 10−4 | 2.4 × 10−3 |
| common | <2.7 × 10−6 | 5.3 × 10−7 | – | – | 8.5 × 10−4 | 2.0 × 10−3 | |||
| CTD + LVOTD | SPRED3 | unfiltered | common + rare | <2.6 × 10−6 | 2.5 × 10−6 | 3.6 × 10−3 | 2.6 × 10−3 | 1.6 × 10−1 | 2.8 × 10−3 |
| common | <2.7 × 10−6 | 3.4 × 10−6 | 3.0 × 10−3 | 3.0 × 10−3 | 1.7 × 10−1 | 2.6 × 10−3 | |||
a
Genes with meta-p values <10−5 and lower than the p values in each dataset included in the meta-analysis.
b
0.05/number of analyzed genes.