Table 5.
Candidate CHD-related MEGs
| Analysis | MEGa | Filter | Variants | Meta-p |
p values for contributing datasets |
|||
|---|---|---|---|---|---|---|---|---|
|
CTD |
LVOTD |
|||||||
| CHOP | PCGC | CHOP | PCGC | |||||
| CTD | EZH2 | CADD10 | common | 3.40 × 10 −2 | 1.22 × 10−1 | 6.50 × 10 −2 | ||
| KDM4A | CADD10 | common | 3.72 × 10 −2 | 1.70 × 10−1 | 4.70 × 10−2 | |||
| KDM4A | CADD10 | common + rare | 3.47 × 10−2 | 1.59 × 10−1 | 4.10 × 10−2 | |||
| KHDC3L | unfiltered | rare | 3.38 × 10−2 | 6.40 × 10−2 | 1.47 × 10−1 | |||
| RNF2 | CADD10 | common + rare | 1.03 × 10−2 | 3.40 × 10−2 | 9.70 × 10−2 | |||
| TRIP13 | CADD10 | rare | 1.28 × 10−2 | 2.00 × 10−2 | 1.29 × 10−1 | |||
| LVOTD | CDC20 | unfiltered | common | 3.34 × 10−2 | 8.30 × 10−2 | 1.15 × 10−1 | ||
| CDC20 | unfiltered | common + rare | 3.58 × 10−2 | 1.27 × 10−1 | 7.20 × 10−2 | |||
| CDX2 | unfiltered | common | 1.02 × 10−2 | 2.00 × 10−2 | 1.69 × 10−1 | |||
| CDX2 | unfiltered | common + rare | 1.65 × 10−2 | 2.60 × 10−2 | 2.24 × 10−1 | |||
| DNMT3A | CADD10 | rare | 1.05 × 10−2 | 5.60 × 10−2 | 4.30 × 10−2 | |||
| IGF2BP2 | CADD10 | rare | 4.67 × 10−2 | 1.06 × 10−1 | 1.16 × 10−1 | |||
| KDM4A | unfiltered | common | 1.69 × 10−2 | 6.20 × 10−2 | 6.30 × 10−2 | |||
| KDM4A | unfiltered | common + rare | 1.29 × 10−2 | 6.50 × 10−2 | 4.50 × 10−2 | |||
| KDM4A | CADD10 | rare | 6.34 × 10−3 | 2.00 × 10−2 | 8.60 × 10−2 | |||
| KMT2D | unfiltered | common | 3.93 × 10−2 | 1.04 × 10−1 | 1.02 × 10−1 | |||
| KMT2D | unfiltered | common + rare | 4.52 × 10−2 | 1.25 × 10−1 | 9.70 × 10−2 | |||
| PUM1 | CADD10 | rare | 4.19 × 10−3 | 3.60 × 10−2 | 3.40 × 10−2 | |||
| SMARCA4 | CADD10 | common + rare | 1.89 × 10−2 | 5.90 × 10−2 | 9.00 × 10−2 | |||
| CTD + LVOTD | BCAS2 | unfiltered | common | 2.04 × 10−2 | 2.60 × 10−2 | 4.64 × 10−1 | 1.03 × 10−1 | 4.78 × 10−1 |
| CTCF | CADD10 | rare | 3.20 × 10−2 | 6.40 × 10−2 | 2.20 × 10−1 | 4.17 × 10−1 | 1.35 × 10−1 | |
| KDM4A | unfiltered | common | 2.53 × 10−2 | 5.19 × 10−1 | 6.60 × 10−2 | 6.20 × 10−2 | 6.30 × 10−2 | |
| KDM4A | unfiltered | common + rare | 2.21 × 10−2 | 5.19 × 10−1 | 6.50 × 10−2 | 6.50 × 10−2 | 4.50 × 10−2 | |
| KDM4A | CADD10 | common + rare | 1.27 × 10−2 | 1.59 × 10−1 | 4.10 × 10−2 | 1.37 × 10−1 | 2.28 × 10−1 | |
| KDM4A | CADD10 | rare | 1.32 × 10−2 | 2.24 × 10−1 | 2.74 × 10−1 | 2.00 × 10−2 | 8.60 × 10−2 | |
| KHDC3L | unfiltered | rare | 4.07 × 10−2 | 6.40 × 10−2 | 1.47 × 10−1 | 3.12 × 10−1 | 4.91 × 10−1 | |
| KMT2D | unfiltered | common | 3.03 × 10−2 | 1.80 × 10−1 | 2.80 × 10−1 | 1.04 × 10−1 | 1.02 × 10−1 | |
| KMT2D | unfiltered | common + rare | 3.67 × 10−2 | 1.93 × 10−1 | 2.94 × 10−1 | 1.25 × 10−1 | 9.70 × 10−2 | |
| PUM1 | CADD10 | rare | 3.58 × 10−3 | 2.58 × 10−1 | 5.60 × 10−2 | 3.60 × 10−2 | 3.40 × 10−2 | |
| RNF2 | CADD10 | common | 9.60 × 10−3 | 1.70 × 10−2 | 7.00 × 10−2 | 1.10 × 10−1 | 8.12 × 10−1 | |
| TRIP13 | CADD10 | rare | 2.52 × 10−3 | 2.00 × 10−2 | 1.29 × 10−1 | 3.20 × 10−2 | 3.72 × 10−1 | |
a
MEGs with meta-p values <0.05 and lower than the p values in each dataset included in the meta-analysis.