Table 2.

Steady State etanercept O-glycovariant binding affinity to TNF-α with association and dissociation rates

	KD (M)		Ka (1/Ms)		Kd (1/s)
	Avg.	S.D.	Avg.	S.D.	Avg.	S.D.
Ref	2.50E-10	5.69 × 10−11	1.58 × 106	4.94 × 105	1.74 × 10−4	6.36 × 10−5
Etan-C1	2.28E-10	9.26 × 10−11	1.30 × 106	3.11 × 104	1.87 × 10−4	5.80 × 10−5
Etan-Tn	1.33E-10	4.60 × 10−11	1.82 × 106	4.45 × 105	1.14 × 10−4	7.42 × 10−5
Etan-C1-STn	2.46 × 10−11	6.08 × 10−12	1.84 × 106	5.04 × 105	1.84 × 10−4	9.79 × 10−5
Etan-S/Tn	1.89 × 10−11	4.81 × 10−12	2.07 × 106	1.77 × 105	7.38 × 10−5	9.72 × 10−5
Etan-C1-C3	3.97E-10	6.22 × 10−11	1.38 × 106	4.88 × 104	1.93 × 10−4	1.35 × 10−4
Etan-C3	5.85E-10	2.12–10	8.75 × 105	5.89 × 104	2.64 × 10−4	8.26 × 10−5

Avg, Average; SD, standard deviation.