Table 3.
Differentially expressed proteins (FDR < 0.05) for top 10 increased (fold change > 1) and decreased proteins (fold change < 1) for GBM versus control and their fold change values for GBM subtype (PRO, MES, CLA) versus control comparisons
| Proteins | Fold change |
|||
|---|---|---|---|---|
| GBM versus Control | PRO versus Control | MES versus Control | CLA versus Control | |
| Top-10 increased proteins | ||||
| Von Willebrand factor A domain-containing protein 1 | 1.6 | 190.1 | − | 245.5 |
| Adipocyte enhancer-binding protein 1 | 1.4 | 38.5 | − | − |
| Prolargin | 1.3 | 27.6 | − | − |
| Osteopontin | 1.3 | − | − | |
| Cathepsin Z | 1.3 | 19.6 | 26.8 | − |
| Collagen alpha-1(XVI) chain | 1.2 | 14.6 | 11.1 | − |
| Periostin | 1.2 | − | − | − |
| Kininogen-1 | 1.2 | 12.5 | − | 15.6 |
| Fibulin-5 | 1.2 | − | − | − |
| Collagen alpha-2(VI) chain | 1.2 | − | − | − |
| Top-10 Decreased Proteins | ||||
| Leucine-rich glioma-inactivated protein 1 | −1.4 | − | − | |
| Hyaluronan and proteoglycan link protein 2 | −1.2 | − | − | |
| Protein S100-A1 | −1.1 | − | − | |
| Tenascin-R | −1 | −3.2 | −4.8 | − |
| Hyaluronan and proteoglycan link protein 1 | −1 | − | −3.8 | − |
| EMILIN-2 | −1 | − | − | − |
| Laminin subunit beta-2 | −1 | − | −2.4 | − |
| Decorin | −1 | − | −2.7 | − |
Abbreviations: CLA, classical; GBM, glioblastoma; MES, mesenchymal; PRO, proneural.