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. 2022 Mar 25;23:18. doi: 10.1186/s40360-022-00555-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Bioinformatics analysis for effects of propofol on the gene expression profiles according to GSE106799 datasets. Using data from GSE106799 dataset, we performed Gene cluster GO analysis revealed the biological functions of neurons influenced by propofol. A, the up-regulated genes after propofol treatment are primarily associated to biological functions, such as cell signal, cell proliferation, response to hypoxia and so on. B, the down-regulated genes after propofol treatment are related to biological functions, such as feeding behavior, long-term memory, negative regulation of transcription, and so on. Treatment with propofol decreased the expression of Arc, DNMT3A and DNMT3B (C, D & E, respectively). GO, Gene Ontology