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. 2022 Mar 25;23:18. doi: 10.1186/s40360-022-00555-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — DEX pretreatment reduces the propofol-induced neuronal injury in mouse hippocampus. A hippocampal neuronal apoptosis in mouse brains measured with TUNEL staining; B Arc positive expression detected with immunohistochemistry in rat hippocampus; C miR-377-5p expression and Arc mRNA expression quantified using PR-qPCR; D protein levels of DNMT3A, DNMT3B, and Arc measured using western blot analysis, and the full-length blots/gels are presented in Figure S2. Each value represents the mean ± SD for n = 3. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. DEX, dexmedetomidine; TUNEL, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling