TABLE 2.
Information of 23 hub genes identified by RNA-seq analysis across the three groups.
| Hub gene | PTZ vs. Con. | Q808 vs. PTZ | ||
|---|---|---|---|---|
| Log2FC | p-value | Log2FC | p-value | |
| Ace (angiotensin I converting enzyme) | −1.136 | 0.049 | 1.918 | 0.005 |
| Alas2 (5′-aminolevulinate synthase 2) | 1.110 | 0.030 | 1.123 | 0.027 |
| Ccdc88b (coiled-coil domain containing 88B) | −0.868 | 0.031 | 1.119 | 0.021 |
| Col18a1 (collagen type XVIII alpha 1 chain) | −0.666 | 0.034 | 0.963 | 0.012 |
| Doc2a (double C2 domain alpha) | 1.006 | 0.002 | −0.950 | 0.023 |
| Enpp2 (ectonucleotide pyrophosphatase/phosphodiesterase 2) | −0.703 | 0.014 | 1.639 | 0.023 |
| Faap100 (Fanconi anemia core complex-associated protein 100) | −0.840 | 0.016 | 0.839 | 0.045 |
| Fbl (fibrillarin) | 0.987 | 0.037 | −1.326 | 0.041 |
| Fhl2 (four and a half LIM domains 2) | 0.990 | 0.010 | −0.969 | 0.049 |
| Gypc (glycophorin C) | 1.380 | 0.001 | −1.003 | 0.030 |
| Hbb (hemoglobin subunit beta) | 0.776 | 0.026 | 1.303 | 0.001 |
| Itpripl1 (inositol 1,4,5-trisphosphate receptor interacting protein-like 1) | −1.107 | 0.044 | 2.032 | 0.036 |
| LOC102556346 (angiotensin-converting enzyme-like) | −0.978 | 0.005 | 1.696 | 0.004 |
| LOC103692570 (dihydropyrimidinase-related protein 5-like) | 1.387 | 0.019 | −4.768 | 0.001 |
| Lmo4 (LIM domain only 4) | 0.709 | 0.018 | −1.197 | 0.002 |
| Man2b2 (mannosidase, alpha, class 2B, and member 2) | −0.7607 | 0.017 | 1.040 | 0.007 |
| Mex3a (mex-3 RNA binding family member A) | 1.354 | 0.001 | −1.790 | 0.002 |
| Mvd (mevalonate diphosphate decarboxylase) | 0.742 | 0.031 | −0.938 | 0.036 |
| Ovol2 (ovo-like zinc finger 2) | 2.552 | 0.001 | −1.630 | 0.032 |
| Shox2 (short stature homeobox 2) | −3.674 | 0.012 | 5.274 | 0.001 |
| Slc25a22 (solute carrier family 25 member 22) | 1.588 | 0.024 | −2.363 | 0.015 |
| Sox11 (SRY box 11) | 2.712 | 0.027 | −3.280 | 0.040 |
| Wdr54 (WD repeat domain 54) | 0.931 | 0.020 | −1.067 | 0.029 |