TABLE 4.
Hub genes related to epilepsy.
| Gene | Relationship with epilepsy | References |
|---|---|---|
| Ace | Carbamazepine inhibits Ace and influences the pathogenesis of temporal lobe epilepsy | Almeida et al. (2012) |
| Doc2a | A novel Ca2+ sensor for synaptic transmission; increased in human and rat temporal lobe epilepsy | Hu et al. (2019) |
| Shox2 | A transcriptional regulator of ion channels; loss of Shox2 could alter firing frequency and thereby influence the susceptibility to seizure generation | (Yu et al., 19912021) |
| Slc25a22 | Contributes to the genesis and control of myoclonic seizures | Molinari et al. (2005) |
| Hbb | Increased in cortical tissue samples from patients with mesial temporal lobe epilepsy | Guelfi et al. (2019) |
| Fh12 | Associated with the KCNE1 (minK) potassium channel; decreased in human mesial temporal lobe epilepsies | Jamali et al. (2006) |
| Col18a1 | Encodes the collagen XVIII protein; inactivation of collagen XVIII results in improper neuronal cell migration | Ackley et al. (2001) |
| Ovol2 | A key regulator of neural development; required for efficient migration | Mackay et al. (2006) |
| Sox11 | A transcription factor; plays an important role in proliferation, maturation, and differentiation of newborn neurons | Faigle and Song (2013) |
| Lmo4 | Regulates calcium-induced calcium release in central neurons and modulates synaptic plasticity in the hippocampus | Qin et al. (2012) |