Table 1.
Averaged intrinsic solubility of 32 drugs at 25 °C with the poorest interlaboratory reproducibility
| Compound | log S025 (M) |
SD a | n b | Compound | log S025 (M) |
SD | n |
|---|---|---|---|---|---|---|---|
| Clofazimine | -9.05 | 0.93 | 5 | Amiodarone | -10.41 | 0.59 | 4 |
| Telmisartan | -6.73 | 0.84 | 5 | Saquinavir | -5.92 | 0.58 | 3 |
| Buprenorphine | -6.07 | 0.83 | 3 | Quinine | -3.06 | 0.57 | 7 |
| Mifepristone | -5.22 | 0.75 | 4 | Diflunisal | -4.99 | 0.56 | 11 |
| Tamoxifen | -7.52 | 0.72 | 7 | Raloxifene | -6.82 | 0.56 | 6 |
| Terfenadine | -7.74 | 0.71 | 11 | Diphenhydramine | -3.21 | 0.55 | 4 |
| Sulfadimethoxine | -3.74 | 0.70 | 3 | Etoxadrol | -1.96 | 0.55 | 3 |
| Curcumin | -5.36 | 0.68 | 3 | Didanosine | -1.24 | 0.54 | 3 |
| Rifabutin | -4.09 | 0.66 | 3 | Danazol | -6.10 | 0.52 | 10 |
| Iopanoic_Acid | -5.49 | 0.66 | 3 | Ezetimibe | -4.94 | 0.51 | 4 |
| Pioglitazone | -6.20 | 0.66 | 4 | Chlorprothixene | -5.99 | 0.51 | 6 |
| Amodiaquine | -5.49 | 0.65 | 3 | Bromocriptine | -5.50 | 0.51 | 5 |
| Fentiazac | -5.84 | 0.65 | 4 | Miconazole | -5.82 | 0.50 | 6 |
| Itraconazole | -8.98 | 0.61 | 3 | Omeprazole | -3.70 | 0.50 | 3 |
| Procaine | -2.30 | 0.60 | 3 | Amantadine | -2.19 | 0.50 | 3 |
| Bisoprolol | -2.09 | 0.59 | 3 | Thiabendazole | -3.97 | 0.50 | 4 |
a Calculated interlaboratory standard deviation.
b Number of reported studies from different laboratories.