Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 5;7(2):106–130. doi: 10.5599/admet.661

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 by the authors.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Figure 6. — The pH-solubility profile of ketoconazole determined by using different amounts of 1:1 molar physical mixtures of ketoconazole and fumaric acid and equilibrating for 96 h. The pH-solubility profile of ketoconazole determined by pH adjustment with HCl is also superimposed for comparison. The solubility profiles from a narrow pH range (boxed region) is shown in expanded scale in the inset to indicate decrease in ketoconazole solubility after conversion to cocrystal during dissolution of the physical mixture. Asterisk symbols in the figure indicates solubility where both ketoconazole and its cocrystal with fumaric acid coexist in the solid phase.