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. 2019 Apr 5;7(2):106–130. doi: 10.5599/admet.661

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This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 7. — The pH-solubility profile of ketoconazole determined by using different amounts of 1:1 molar physical mixtures of ketoconazole and succinic acid and equilibrating for 96 h. The pH-solubility profile of ketoconazole determined by pH adjustment with HCl is also superimposed for comparison. The solubility profiles from a narrow pH range (boxed region) is shown in expanded scale in the inset to indicate decrease in ketoconazole solubility after conversion to cocrystal during dissolution of the physical mixture. Asterisk symbols in the figure indicates solubility where both ketoconazole and ketoconazole-succinic acid cocrystals coexist in the solid phase.