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. 2019 Jun 5;7(3):210–219. doi: 10.5599/admet.698

Table 1.

Averaged Saturation Shake-Flask (SSF) and CheqSol (CS) Intrinsic Solubility (log molar) a

Compound avg. 25 °C log S0SSF SDSSF N avg. 25 °C log S0CS SD CS N Ref. (CheqSol)
Acebutolol -2.50 0.42 2 -2.68 0.31 1 [17]
Acetaminophen -0.97 0.10 18 -1.03 0.05 2 [16,22]
Acetazolamide -2.38 0.18 10 -2.44 0.04 1 [16]
Alprenolol -2.83 0.16 1 -2.66 0.04 2 [22,28]
Amantadine -2.76 0.50 1 -1.90 0.07 2 [22,29]
Amiodarone -10.58 0.35 4 -9.68 0.15 1 [22]
Amitriptyline -4.66 0.40 5 -4.55 0.15 1 [22]
Amodiaquine -4.74 0.35 1 -5.87 0.10 2 [16,22]
Amoxicillin -2.13 0.06 10 -1.97 0.08 1 [17]
Aripiprazole -6.74 0.16 2 -6.43 0.30 1 [28]
Atenolol -1.20 0.06 7 -1.25 0.06 4 [22,23,27,28]
Atropine -2.01 0.29 4 -2.00 0.07 1 [16]
Barbital,Hexo- -2.79 0.15 5 -2.67 0.07 1 [16]
Barbital,Pheno- -2.30 0.08 25 -2.29 0.07 1 [22]
Bendroflumethiazide -4.35 0.34 4 -4.19 0.15 2 [24,29]
Benzocaine -2.18 0.12 13 -2.33 0.31 1 [17]
Benzoic_Acid -1.59 0.05 12 -1.61 0.15 1 [22]
Benzoic_Acid,4-Hydroxy- -1.38 0.10 5 -1.46 0.04 1 [22]
Benzthiazide -4.84 0.28 4 -4.86 0.04 2 [22,24]
Bifonazole -6.27 0.25 4 -6.01 0.15 1 [25]
Bisoprolol -2.40 0.34 2 -1.46 0.26 1 [28]
Bupivacaine -3.47 0.18 9 -3.08 0.21 2 [16,24]
Carprofen -4.63 0.05 1 -4.70 0.22 1 [22]
Carvedilol -5.46 0.36 12 -4.46 0.27 1 [28]
Cephalothin -3.40 0.32 1 -2.94 0.04 1 [16]
Chlorpheniramine -2.65 0.10 1 -2.60 0.12 3 [21,22]
Chlorpromazine -5.45 0.31 11 -5.55 0.04 1 [22]
Chlorpropamide -3.15 0.17 5 -3.21 0.05 2 [16,28]
Chlorprothixene -5.66 0.38 3 -6.31 0.44 3 [16,22]
Chlorzoxazone -2.78 0.11 3 -2.64 0.04 2 [16,29]
Cimetidine -1.50 0.22 7 -1.69 0.04 1 [16]
Ciprofloxacin -3.57 0.19 19 -3.60 0.18 1 [22]
Cyproheptadine -5.02 0.46 4 -5.00 0.15 1 [24]
Diazoxide -3.46 0.26 3 -3.36 0.07 1 [16]
Dibucaine -3.70 0.35 1 -4.20 0.26 2 [17,24]
Diclofenac -5.33 0.19 27 -5.40 0.14 6 [9,21,22,24,26]
Diethylstilbestrol -4.38 0.38 6 -4.43 0.48 1 [17]
Difloxacin -3.94 0.10 2 -3.60 0.04 1 [16]
Diflunisal -5.08 0.40 5 -4.92 0.70 6 [17,21]
Diltiazem -2.95 0.20 1 -3.05 0.16 2 [22]
Diphenhydramine -3.29 0.64 3 -2.95 0.04 1 [22]
Dipyridamole -5.13 0.13 10 -5.16 0.02 1 [17]
Enrofloxacin -3.16 0.13 7 -3.18 0.18 1 [16]
Famotidine -2.67 0.27 5 -2.65 0.04 1 [22]
Fenoprofen -3.92 0.20 1 -3.70 0.26 1 [16]
Flufenamic_Acid -5.27 0.28 10 -5.35 0.04 1 [22]
Flumequine -4.10 0.08 1 -3.80 0.11 2 [16,22]
Flurbiprofen -4.36 0.19 21 -4.05 0.15 2 [16,22]
Fluvastatin -3.78 0.06 1 -3.87 0.16 1 [28]
Furosemide -4.51 0.20 19 -4.18 0.12 3 [21,22]
Glibenclamide -6.63 0.45 10 -6.41 0.07 2 [27,28]
Gliclazide -4.27 0.40 14 -4.20 0.15 3 [23,27,28]
Glimepiride -7.22 0.42 5 -6.44 0.15 1 [27]
Glipizide -5.66 0.24 6 -5.51 0.10 3 [27-29]
Guanine -4.09 0.07 2 -4.43 0.37 1 [16]
Haloperidol -5.76 0.14 8 -5.52 0.19 2 [22,24]
Hydroflumethiazide -2.72 0.11 15 -2.70 0.03 3 [21,29]
Hydrochlorothiazide -3.08 0.08 5 -2.97 0.44 1 [16]
Ibuprofen -3.80 0.22 19 -3.97 0.23 4 [21-23]
Imipramine -4.39 0.28 7 -4.15 0.13 4 [17,21,22]
Ketoprofen -3.45 0.23 20 -3.23 0.02 4 [17,21,24]
Lidocaine -1.82 0.08 19 -1.87 0.05 1 [22]
Loperamide -6.80 0.32 3 -7.10 0.04 2 [16,22]
Maprotiline -4.54 0.26 3 -4.75 0.08 2 [22,24]
Meclizine -5.55 0.66 1 -6.48 0.15 1 [29]
Meclofenamic_Acid -6.88 0.08 2 -6.56 0.42 2 [17,22]
Mefenamic_Acid -6.36 0.42 6 -6.54 0.28 2 [16,22]
Metoclopramide -3.18 0.28 1 -3.58 0.07 1 [29]
Metoprolol -1.31 0.16 2 -1.22 0.01 2 [22,28]
Metronidazole -1.25 0.06 17 -1.22 0.04 1 [16]
Miconazole -6.04 0.41 4 -5.38 0.45 2 [16,22]
Nadolol -1.29 0.40 2 -1.63 0.08 2 [22,28]
Nalidixic_Acid -3.76 0.26 8 -3.61 0.04 1 [16]
Naphthoic_Acid,2- -3.82 0.28 5 -3.77 0.15 1 [22]
Naphthol,1- -2.09 0.10 6 -1.98 0.07 1 [22]
Naproxen -4.21 0.14 15 -4.41 0.25 2 [16,22]
Niflumic_Acid -4.18 0.13 6 -4.11 0.08 2 [16,22]
Nitrofurantoin -3.34 0.11 11 -3.29 0.06 2 [16,22]
Norfloxacin -2.88 0.16 18 -2.75 0.15 1 [22]
Nortriptyline -3.94 0.23 3 -3.93 0.02 2 [16,22]
Ofloxacin -1.37 0.14 6 -1.27 0.04 1 [16]
Olanzapine -4.47 0.17 1 -4.23 0.18 1 [24]
Orphenadrine -3.71 0.35 1 -3.17 0.15 1 [22]
Paliperidone -4.56 0.18 1 -4.31 0.22 1 [28]
Papaverine -4.40 0.14 8 -4.21 0.24 4 [16,21,22,24]
Phenazopyridine -3.99 0.16 6 -4.19 0.07 1 [16]
Phenol,4-Iodo- -1.83 0.07 1 -1.72 0.04 1 [22]
Phenylbutazone -4.51 0.36 10 -4.39 0.04 1 [22]
Phenytoin -4.08 0.13 29 -3.86 0.18 1 [16]
Phthalic_Acid,2- -1.46 0.02 10 -1.55 0.08 2 [16,22]
Pindolol -3.81 0.14 6 -3.64 0.13 3 [22,24,28]
Pioglitazone -6.21 0.81 3 -6.16 0.46 1 [28]
Piroxicam -4.46 0.26 16 -4.73 0.06 4 [16,21,22]
Pramoxine -3.46 0.39 1 -3.02 0.15 1 [22]
Probenecid -4.82 0.24 3 -4.86 0.04 1 [17]
Procaine -2.59 0.46 2 -1.72 0.07 1 [22]
Prochlorperazine -4.38 0.26 1 -4.75 0.15 1 [22]
Promethazine -4.39 0.19 10 -4.26 0.15 1 [22]
Propranolol -3.82 0.30 4 -3.49 0.06 6 [21-24,27,28]
Pyrimethamine -3.96 0.57 3 -4.11 0.22 1 [22]
Quinine -3.16 0.67 5 -2.80 0.01 2 [16,22]
Ranitidine -1.70 0.57 1 -2.50 0.26 1 [16]
Rosiglitazone -5.28 0.50 3 -5.22 0.61 1 [28]
Salicylic_Acid -1.88 0.08 20 -1.93 0.04 1 [17]
Sertraline -5.41 0.28 2 -4.83 0.15 1 [22]
Sulfacetamide -1.50 0.05 5 -1.52 0.04 1 [16]
Sulfamerazine -3.10 0.07 6 -3.12 0.05 1 [22]
Sulfamethazine -2.63 0.27 6 -2.73 0.04 1 [16]
Sulfamethizole -2.77 0.14 5 -2.78 0.14 1 [17]
Sulfasalazine -6.47 0.08 7 -6.21 0.10 2 [16,22]
Sulfathiazole -2.61 0.23 8 -2.69 0.15 1 [22]
Terfenadine -7.68 0.71 10 -8.40 0.15 1 [29]
Tetracaine -3.22 0.11 1 -3.05 0.06 2 [16,24]
Tetracycline -3.29 0.05 6 -3.00 0.09 2 [16,29]
Tetracycline,Oxy- -3.27 0.07 4 -3.09 0.33 1 [16]
Thiabendazole -4.13 0.46 3 -3.48 0.10 1 [17]
Thymol -2.18 0.05 3 -2.19 0.04 1 [22]
Tolbutamide -3.55 0.11 5 -3.50 0.05 2 [17,28]
Tolmetin -4.05 0.15 1 -4.11 0.03 2 [16,22]
Trazodone -3.31 0.09 4 -3.19 0.40 2 [17]
Trichlormethiazide -3.64 0.12 3 -3.38 0.18 3 [16,22]
Trimethoprim -2.64 0.39 9 -2.95 0.15 1 [16]
Verapamil -4.36 0.28 9 -4.07 0.22 3 [21,22]
Warfarin -4.77 0.22 9 -4.80 0.14 2 [22,24]

a SD refers to the standard deviation of reported values from N different sourcs. The average interlaboratory SDi values for for the two sets of data are: SDiSSF = 0.24 and SDiCS = 0.15 log unit.