Table 2.
Effect of insulin and glucose in RPMI medium with human plasma (50 % v/v; RPMI-P) on the MIC (μg/ml)
| Organism | Drug | RPMI-Pc | Ratio RPMI-P RPMI |
RPMI-P & Glud | Ratio RPMI-P & Gluc RPMI-P |
RPMI-P & Insue | Ratio RPMI-P & Insu RPMI-P |
RPMI-P, Gluc & Insu | Ratio RPMI-P, Gluc & Insu RPMI-P |
|---|---|---|---|---|---|---|---|---|---|
| C. lusitaniae | AmBa | 0.078 (S)b | 2 | 9.75x10-3 (S) | 0.25 | 0.0195 (S) | 0.25 | 0.0195 (S) | 0.25 |
| 5-FCa | 0.78 (S) | 5 | 0.78 (S) | 1 | 0.78 (S) | 1 | 0.78 (S) | 1 | |
| Flucona | 1.0 (S) | 0.25 | 1.0 (S) | 1 | 4.0 (S) | 4 | 4.0 (S) | 1 | |
| Itraa | 2.0 (R) b | 4 | 2.0 (R) | 1 | 2.0 (R) | 1 | 2.0 (R) | 1 | |
| Micona | >36.075 (R) | >185 | >36.075 (R) | ≥1 | 0.3608 (S) | 0.01 | >36.08 (R) | ≥1 | |
| C. parapsilosis | AmB | 0.0195 (S) | 0.25 | 0.078 (S) | 4 | 0.039 (S) | 2 | 0.0195 (S) | 1 |
| 5-FC | 24.96 (I) b | 32 | 24.96 (I) | 1 | 24.96 (I) | 1 | 24.96 (I) | 1 | |
| Flucon | 1.0 (S) | 0.5 | 0.5 (S) | 0.5 | 8.0 (S) | 8 | 0.5 (S) | 0.5 | |
| Itra | 0.125 (S) | 0.5 | 0.125 (S) | 1 | 0.125 (S) | 1 | 0.5 (S-DD) | 2 | |
| Micon | >39.88 (R) | >92 | >39.88 (R) | 1 | >39.88 (R) | ≥1 | >39.88 (R) | ≥1 | |
| C. albicans | AmB | 0.00975 (S) | 0.25 | 0.0195 (S) | 2 | 0.0195 (S) | 2 | 0.0195 (S) | 2 |
| 5-FC | 3.12 (S) | 4 | 3.12 (S) | 1 | 3.12 (S) | 1 | 3.12 (S) | 1 | |
| Flucon | 0.075 (S) | 0.5 | 0.075 (S) | 1 | >6.8 (S-R) | 1024 | 0.3 (S) | 4 | |
| Itra | 0.03125 (S) | 1 | 0.03125 (S) | 1 | 0.03125 (S) | 1 | 0.03125 (S) | 1 | |
| Micon | 0.39 (S) | 1 | 0.065 (S) | 0.166 | 0.0325 (S) | 0.083 | 0.78 (S) | 2 | |
| C. tropicalis | AmB | 0.0195 (S) | 0.5 | 0.0195 (S) | 1 | 0.0195 (S) | 1 | 0.0195 (S) | 1 |
| 5-FC | 3.12 (S) | 16 | 3.12 (S) | 1 | 3.12 (S) | 1 | 3.12 (S) | 1 | |
| Flucon | >128 (R) | >1 | >128 (R) | 1 | >128.0 (R) | >1 | >128.0 (R) | 1 | |
| Itra | >64 (R) | 1 | >64 (R) | 1 | >64.0 (R) | 1 | >64.0 (R) | 1 | |
| Micon | >35.88 (R) | >23 | >35.88 (R) | 1 | >35.88 (R) | ≥1 | >35.88 (R) | ≥1 | |
| C. neoformans | AmB | 0.00488 (S) | 0.125 | 0.00975 (S) | 2 | 0.00975 (S) | 1 | 0.00975 (S) | 2 |
| 5-FC | 25.0 (I-R) | 4 | 12.5 (I) | 0.5 | 12.5 (I) | 0.5 | 12.5 (I) | 0.5 | |
| Flucon | 1.0 (S) | 0.125 | 0.25 (S) | 0.25 | 1.0 (S) | 1 | 2.0 (S) | 2 | |
| Itra | 0.25 (S-DD)b | 0.5 | 0.25 (S-DD) | 1 | 0.0125 (S) | 0.05 | 0.25 (S-DD) | 1 | |
| Micon | 1.953 (S) | 2 | 0.3906 (S) | 0.2 | 0.078 (S) | 0.04 | 7.812 (R) | 4 | |
| C. glabrata | AmB | 3.71x10-5 (S) | 4.76x10-4 | 3.7 x 10-5 (S) | 1 | 3.71x10-5(S) | 1 | 3.71x10-5 (S) | 1 |
| 5-FC | 0.0615 (S) | 7.69x10-3 | <0.0615 (S) | <1 | <0.0615 (S) | ≤1 | 0.246 (S) | 4 | |
| Flucon | <2.4x10-5(S) | <2.4x10-4 | <2.4x10-5 (S) | <1 | <2.4x10-5(S) | 1 | <2.4x10-5(S) | ≤1 | |
| Itra | 0.0194 (S) | 9.7x10-3 | 0.0194 (S) | 1 | 0.0194 (S) | 1 | 0.0194 (S) | 1 | |
| Micon | 1.08x10-3 (S) | 2.8x10-3 | 5.41 x 10-4(S) | 0.5 | 0.0964 (S) | 89 | 0.001083 (S) | 1 | |
| C. krusei | AmB | 0.156 (S) | 2 | 0.624 (S) | 4 | 0.156 (S) | 1 | 0.156 (S) | 1 |
| 5-FC | >25.0 (I-R) | >2 | >25.0 (I-R) | 1 | >25.0 (I-R) | ≥1 | >25.0 (I-R) | ≥1 | |
| Flucon | 64.0 (R) | 1 | 64.0 (R) | 1 | 64.0 (R) | 1 | 64.0 (R) | 1 | |
| Itra | 4.0 (R) | 4 | 4.0 (R) | 1 | 4.0 (R) | 1 | 4.0 (R) | 1 | |
| Micon | 35.88 (R) | >92 | 8.97 (R) | 0.25 | 574.08 (R) | 16 | >35.88 (R) | ≥1 |
aamphotericin B (AmB), flucytosine (5-FC) fluconazole (Flucon), itraconazole (Itra), and miconazole (Micon)
bS=sensitive; R=resistant; I=intermediate resistance; S-DD= sensitive based on reported disc diffusion concentration
cP=plasma
dGluc=glucose
eInsu=insulin