TABLE 1.
Serum creatinine and BUN levels in infected rabbits treated with various antifungal drug regimens for up to 21 days
| Drug(s) (n) | Mean serum creatinine/BUN levelsa ± 1 SD on day:
|
|||
|---|---|---|---|---|
| 0 | 5 | 14 | 21 | |
| Control (7) | 0.8 ± 0.1/19.4 ± 2.3 | 2.4 ± 0.7/44.5 ± 4.1 | ||
| 5FC (4) | 0.8 ± 0.1/20.2 ± 3.4 | 0.9 ± 1.0/28.2 ± 3.6 | ||
| AmB (4) | 0.9 ± 0.1/19.1 ± 1.8 | 0.8 ± 0.1/22.7 ± 2.4 | 1.1 ± 0.1/24.3 ± 2.6 | 1.2 ± 0.1/25.2 ± 2.2 |
| Flu (4) | 0.9 ± 0.1/20.3 ± 1.9 | 0.8 ± 0.2/25.4 ± 2.6 | 0.9 ± 0.1/24.6 ± 2.0 | 1.0 ± 0.0/24.7 ± 1.6 |
| AmB + Flu (4) | 0.8 ± 0.0/19.8 ± 2.3 | 0.9 ± 0.1/24.4 ± 2.3 | 1.0 ± 0.2/25.1 ± 2.6 | 1.1 ± 0.1/23.2 ± 2.2 |
| Flu + 5FC (4) | 0.8 ± 0.1/19.6 ± 2.8 | 0.8 ± 0.1/22.1 ± 2.8 | 0.8 ± 0.1/23.4 ± 2.2 | 0.9 ± 0.1/20.3 ± 1.8 |
a
On day 0, creatinine and BUN levels in serum collected from rabbits were measured before the rabbits received their first dose of antifungal drug(s). Serum creatinine and BUN concentrations in healthy, noninfected rabbits (n = 4) were 0.82 ± 0.05 and 20.4 ± 2.1 mg/dl, respectively.