TABLE 5.
Numbers of samples from the various sites that were culture negative after 5, 14, or 21 days of therapy
| Site and drug(s) | No. of culture-negative samples/total no. of samples after indicated days of therapyd
|
||
|---|---|---|---|
| 5 | 14 | 21 | |
| Vitreous humor | |||
| Control | 0/22 (0)a | ||
| AmB | 3/12 (25)a | 16/16 (100) | 16/16 (100) |
| Flu | 12/12 (100)c | 16/16 (100) | 16/16 (100) |
| 5FC | 1/12 (17) | 4/4 (100) | No data |
| Flu + 5FC | 12/12 (100)b | 18/18 (100) | 16/16 (100) |
| Flu + AmB | 12/12 (100)b | 16/18 (89) | 13/16 (81) |
| Choroid-retina | |||
| Control | 0/22 (0) | ||
| AmB | 1/12 (8) | 16/16 (100) | 16/16 (100) |
| Flu | 1/12 (8) | 12/16 (75) | 16/16 (100) |
| 5FC | 0/12 (0) | 2/4 (50) | No data |
| Flu + 5FC | 0/12 (0) | 17/18 (94) | 16/16 (100) |
| Flu + AmB | 6/12 (50) | 15/18 (83) | 14/16 (88) |
| Kidney | |||
| Control | 0/11 (0) | ||
| AmB | 4/6 (67) | 8/8 (100) | 8/8 (100) |
| Flu | 0/0 (0) | 4/8 (50) | 8/8 (100) |
| 5FC | 0/6 (0) | 0/2 (0) | No data |
| Flu + 5FC | 0/6 (0) | 6/9 (67) | 6/8 (75) |
| Flu + AmB | 0/6 (0) | 5/9 (56) | 6/8 (88) |
| Valve vegetations | |||
| Control | 0/10 (0) | ||
| AmB | 4/6 (67) | 8/8 (100)a | 8/8 (100)a |
| Flu | 0/6 (0) | 0/8 (0)c | 0/8 (0)c |
| 5FC | 0/6 (0) | 0/2 (0) | No data |
| Flu + 5FC | 0/6 (0) | 5/9 (55) | 3/8 (38) |
| Flu + AmB | 1/6 (17) | 5/9 (55) | 4/8 (50) |
P < 0.0003 versus Flu.
P < 0.003 versus AmB.
P < 0.0003 versus AmB.
The left and right vitreous humor and choroid-retina results were similar. Thus the results were combined. No information was available for the 5FC group on day 21 since all animals in this group died by day 18. Differences between groups were determined by Fisher’s exact test with Bonferroni’s correction. On day 5 seven pair-wise comparisons were made, and a difference of P < 0.007 was considered statistically significant. On days 14 and 21, when a control group did not exist, the 5FC monotherapy group was excluded from analysis because of the small number of subjects. Thus, four pair-wise comparisons were made at these time points and P < 0.01 was considered significant.