Table 3.
Human mitochondrial small subunit components and their contribution to lung diseases
| Component | Disease | Cell Types and Animal Models |
|---|---|---|
| 12S rRNA | COPD | Muscle tissue (18, 19, 41) LHCN-M2 cell line, murine muscle (18) |
| HAPE | Patient’s samples (20) | |
| Infection | PBMC (42) | |
| Inhibition | Blood (43) W1-38 cell line (44) |
|
| IPF | Alveolar macrophage (45) | |
| Lung cancer | Lung tissue (46) | |
| uS2m (MRPS2) | Lung cancer | Lung tissue (27) DLD1 and HTC116 cell lines (28) |
| PH | Mice lung (21) | |
| uS3m (MRPS24) | Lung cancer | DLD1 and HTC116 cell lines (28) |
| uS5m (MRPS5) | Lung cancer | DLD1 and HTC116 cell lines (28) |
| bS6m (MRPS6) | Infection | Macaque lung (47) |
| uS7m (MRPS7) | Lung cancer | Lung tissue (27) |
| uS9m (MRPS9) | ND | |
| uS10m (MRPS10) | COPD | LHCN-M2 cell line (18) |
| uS11m (MRPS11) | Lung cancer | Lung tissue (27, 30) DLD1 and HTC116 cell lines (28) |
| uS12m (MRPS12) | Lung cancer | Lung tissue (27) DLD1 and HTC116 cell lines (28) |
| PH | Murine lung (21) | |
| uS14m (MRPS14) | Lung cancer | Lung tissue (27) DLD1 and HTC116 cell lines (28) |
| uS15m (MRPS15) | Lung cancer | Lung tissue (27) |
| bS16m (MRPS16) | Lung cancer | DLD1 and HTC116 cell lines (28) |
| uS17m (MRPS17) | Asthma | Data mining (34) |
| mS40 (MRPS18B) | Lung cancer | DLD1 and HTC116 cell lines (28) |
| bS18m (MRPS18C) | ND | |
| bS21m (MRPS21) | Lung cancer | DLD1 and HTC116 cell lines (28) |
| PH | Murine lung (21) | |
| mS22 (MRPS22) | COPD | Lung tissue (48) |
| Lung cancer | DLD1 and HTC116 cell lines (28) | |
| mS23 (MRPS23) | ND | |
| mS25 (MRPS25) | Lung cancer | DLD1 and HTC116 cell lines (28) |
| mS26 (MRPS26) | Lung cancer | DLD1 and HTC116 cell lines (28) |
| mS27 (MRPS27) | Lung cancer | Lung tissue (27) |
| bS1m (MRPS28) | Lung cancer | Lung tissue (27) A549 and H1299 cell lines (49) |
| mS29 (MRPS29) | ND | |
| mS31 (MRPS31) | Lung cancer | Lung tissue (27) |
| mS33 (MRPS33) | Lung cancer | Lung tissue (27) |
| mS34 (MRPS34) | Lung cancer | Lung tissue (27) DLD1 and HTC116 cell lines (28) |
| mS35 (MRPS35) | Lung cancer | Lung tissue (27) DLD1 and HTC116 cell lines (28) |
| mS37 (MRPS37) | ND | |
| mS38 (MRPS38) | ND | |
| mS39 (MRPS39, PTCD3) | ND |
S, small; u, universal; b, bacterial; m, mitochondrial; MRP, mitochondrial ribosomal protein; IPF, idiopathic pulmonary fibrosis; COPD, chronic obstructive pulmonary disease; HAPE, high-altitude pulmonary edema; PH, pulmonary hypertension; PBMC, peripheral blood mononuclear cell; ND, not determined. References are shown in parenthesis.