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. 2022 Mar 22;17:1323–1341. doi: 10.2147/IJN.S348598

Table 2.

The Results of the Central Composite Design Test

No. Factors Responsive Values
X1 X2 X3 Size (nm) PDI
1 −1 −1 −1 163.4 0.417
2 −1 −1 0 181.4 0.38
3 −1 −1 1 268.8 0.522
4 −1 0 −1 174.9 0.444
5 −1 0 0 207.6 0.426
6 −1 0 1 197.1 0.493
7 −1 1 −1 221.6 0.536
8 −1 1 0 216.8 0.527
9 −1 1 1 279.8 0.581
10 0 −1 −1 179.6 0.408
11 0 −1 0 174.7 0.347
12 0 −1 1 256 0.553
13 0 0 −1 228.7 0.35
14 0 0 0 185 0.404
15 0 0 1 187.6 0.422
16 0 1 −1 202.7 0.359
17 0 1 0 183.3 0.321
18 0 1 1 207.1 0.482
19 1 −1 −1 170.8 0.325
20 1 −1 0 169.9 0.507
21 1 −1 1 223.1 0.521
22 1 0 −1 152.5 0.434
23 1 0 0 142.8 0.437
24 1 0 1 195.4 0.448
25 1 1 −1 232.4 0.51
26 1 1 0 220.8 0.599
27 1 1 1 232 0.532