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. 2022 Mar 26;72:126977. doi: 10.1016/j.jtemb.2022.126977

Table 3.

Drugs and their potential actions on SARS-CoV-2 [70], [71], [72], [73], [74], [75]

SL. No. Name Action
1. Chloroquine and Hydroxychloroquine Obstructs glycosylation of host receptors and proteolytic processing. Inhibits endosomal acidification by ceasing the production of SARSCoV-2 viral proteins.
2. Lopinavir/ritonavir Repression of 3-chymotrypsin-like protease in the SARS-CoV-2.
3. Nafamostat and Camostat Inhibits transmembrane protease serine 2. Prevents host cell entry.
4. Famotidine A papain-like protease which is encoded by the genome of SARS-CoV-2 is essential for the entry of SARS-CoV-2 into the hostcell, which is restricted by famotidine.
5. Ivermectin Incapacitates cell transport proteins which in turn obstruct their entry into the nucleus.
6. Tocilizumab and Sarilumab Binds with IL-6 receptor. Prevents IL-6 receptor activation. Inhibits IL-6signaling.
7. Remdesivir Gives rise to an active nucleoside triphosphate. Inhibits RNA dependent RNA polymerase.