Table 2.
Comparison of the three groups before and after treatment.
| MET group (n = 54) | SPI group (n = 53) | COM group (n = 51) | ||||
|---|---|---|---|---|---|---|
| Week 0 | Week 12 | Week 0 | Week 12 | Week 0 | Week 12 | |
| Number of menstruation per year (normal ≥8/year) | 5.7 ± 2.1 | 5.9 ± 2.1 | 6.1 ± 1.9 | 6.9 ± 2.4 | 5.8 ± 1.8 | 6.1 ± 2.3 |
| SBP (mm Hg) | 112 ± 11 | 112 ± 11 | 124 ± 13 | 123 ± 11 | 117 ± 9 | 117 ± 8 |
| DBP (mm Hg) | 72 ± 13 | 72 ± 12 | 79 ± 10 | 78 ± 8 | 76 ± 8 | 74 ± 7 |
| Weight (kg) | 63.2 ± 12.4 | 61.8 ± 11.6a | 65.5 ± 16.8 | 63.7 ± 16.2a | 56.5 ± 9.0 | 54.6 ± 8.8 |
| BMI (kg/m2) | 25.6 ± 4.5 | 25.0 ± 4.2 | 25.9 ± 6.7 | 25.2 ± 6.5 | 25.4 ± 3.7 | 24.7 ± 3.6 |
| WHR | 0.87 ± 0.07 | 0.83 ± 0.04 | 0.87 ± 0.09 | 0.82 ± 0.07 | 0.86 ± 0.09 | 0.81 ± 0.10 |
| LH/FSH | 1.67 ± .95 | 1.4 ± 0.90a | 1.86 ± 0.90 | 1.59 ± 0.81a | 2.06 ± 0.99 | 1.92 ± 0.99a |
| TC (mmol/L) | 4.81 ± 1.01 | 4.46 ± 0.68a | 4.91 ± 1.40 | 4.75 ± 0.98 | 4.74 ± 0.98 | 4.64 ± 0.71 |
| TT (nmol/L) | 2.25 ± 1.25 | 2.05 ± 0.89a | 2.09 ± 0.80 | 1.79 ± 0.69a | 2.50 ± 1.03 | 1.88 ± 0.60a |
| FAI | 6.71 ± 8.87 | 5.78 ± 7.62a | 6.99 ± 5.26 | 4.88 ± 4.2a | 7.07 ± 4.21 | 3.58 ± 3.0a |
| QUICKI | 0.33 ± 0.03 | 0.36 ± 0.03a | 0.34 ± 0.03 | 0.34 ± 0.02 | 0.34 ± 0.03 | 0.36 ± 0.03a |
| HOMA-IR | 3.30 ± 2.34 | 1.92 ± 1.07a | 3.02 ± 1.90 | 2.38 ± 1.14a | 2.47 ± 1.63 | 1.71 ± 0.91a |
| HOMA-β | 224.6 ± 166.8 | 1978.0 ± 7068 | 299.6 ± 381 | 867.76 ± 651 | 179.9 ± 99 | 973.7 ± 1264a |
| FBG (mmol/L) | 4.94 ± 0.63 | 4.65 ± 0.45 | 4.79 ± 0.55 | 5.02 ± 0.58 | 4.84 ± 0.61 | 4.68 ± 0.58 |
| FINS (mU/L) | 14.95 ± 9.61 | 9.14 ± 4.81a | 13.87 ± 8.08 | 10.62 ± 4.77a | 11.24 ± 7.1 | 8.15 ± 3.92a |
| mF-G score | 4.2 ± 2.1 | 3.9 ± 1.3 | 4.2 ± 1.3 | 4.1 ± 1.5 | 4.1 ± 1.4 | 4.0 ± 1.2 |
| AUCins | 289.6 ± 151 | 273.3 ± 131a | 282.5 ± 146.4 | 271.2 ± 143.2a | 267.8 ± 126 | 232.1 ± 121.3a |
| AUCglu | 22.8 ± 5.4 | 20.6 ± 4.3a | 21.0 ± 4.8 | 19.2 ± 4.6 | 20.5 ± 5.0 | 17.5 ± 4.2a |
| Rosenfield score | 0.89 ± 1.01 | 0.84 ± 0.98 | 0.90 ± 0.92 | 0.88 ± 0.90 | 0.85 ± 1.05 | 0.83 ± 1.00 |
a P < 0.05 week 0 vs. week 12. MET: metformin; SPI: spironolactone; COM: combined; SBP: systolic blood pressure; DBP: diastolic blood pressure; BMI: body mass index; WHR: waist-hip ratio; LH/FSH: luteinizing hormone/follicular-stimulating hormone; TC: total cholesterol; TT: total testosterone; FAI: free androgen index; QUICKI: quantitative insulin sensitivity check index; HOMA: homeostatic model assessment; IR: insulin resistance; FPG: fasting plasma glucose; FINS: fasting insulin; mG-G score: modified Ferriman–Gallwey score; AUCglu: oral glucose tolerance test area under curve-glucose; AUCins: oral glucose tolerance test area under curve-insulin.