TABLE 2.

Pharmacokinetic parameters

Patient	CLCR (ml/min)	AUC0–∞ (μg · h/ml)	VSS (liters/ kg ABW)	t1/2α (h)	t1/2β (h)	CLT (liters/h)	CLR (liters/h)	24-h urinary excretion (%)
1	182	135	0.37	0.39	2.8	14.0	12.5	90
2	122	196	0.36	0.19	2.2	10.0	9.4	95
3	189	193	0.33	0.37	1.9	9.2	8.2	96
4	191	163	0.48	0.45	3.3	11.1	9.4	82
5	125	258	0.38	0.10	1.9	6.9	6.7	99
6	139	251	0.31	0.63	2.2	7.2	7.8	107
7	164	223	0.43	0.29	4.0	8.4	8.4	98
8	104	294	0.43	0.35	3.0	6.3	5.8	90
9	150	266	0.55	NCa	2.5	7.0	6.3	88
10	NAb	333	0.34	0.28	2.8	5.6	NA	NA
11	184	157	0.50	0.31	3.5	11.3	9.3	82
12	130	215	0.66	0.27	3.1	8.8	5.7	63
Mean (SD)	135 (31)	224 (59)	0.43 (0.10)	0.33 (0.14)	2.8 (0.6)	8.8 (2.4)	8.1 (2.0)	90 (12)

^aNC, not calculated for this patient. 

^bNA, urine data not available for this patient.