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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Curr Opin Struct Biol. 2022 Feb 15;73:102334. doi: 10.1016/j.sbi.2022.102334

Figure 1.

Figure 1

Construction of hybrid and long-range allosteric pathways. (a) Schematic representation of the modular design strategy. Synthetic allosteric communications are established by connecting signaling pathways from different modules. (b) Design long-range allosteric networks to control the functions of proteins of interest (POI) using chemical or light responsive sensor domains. Black dots represent critical residues in the allosteric pathway and white lines indicate covalent or non-covalent interactions.