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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Free Radic Biol Med. 2022 Feb 17;182:23–33. doi: 10.1016/j.freeradbiomed.2022.02.006

Figure 5. Abnormal mitochondrial function in MPAN skin fibroblasts.

Figure 5.

(A) Electron microscopy analysis of mitochondria in cultured human MPAN skin fibroblasts (n = 60 mitochondria from 5 neurons). (B-E) Mitochondria respiration assay of cultured human MPAN skin fibroblasts by Seahorse analyzer (B) and quantification of relative basal oxygen consumption rate (OCR) (C), relative maximal OCR (D) and non-mito OCR (E). Results are representative data (Means ± SE) of three independent experiments. Student’s t test and one-way ANOVA followed by Tukey correction, * P < 0.05, ** P < 0.01, *** P < 0.001, n.s., P > 0.05