Table 1.
Epidemiologic characteristics of the study population according to treatment response to antimalarials
| HCQ Responders (n=22) | HCQ + QC Responders (n = 24) | Nonresponders (n = 19) | p-value | |
|---|---|---|---|---|
| Age, y, mean +/− SEM | 52.2 +/− 4.5 | 45.4 +/− 2.8 | 40.8 +/− 2.3 | 0.05 |
| Sex, n (%) | ns | |||
| Male | 3 (13.6) | 3 (12.5) | 4 (21.1) | |
| Female | 19 (86.4) | 21 (87.5) | 15 (78.9) | |
| Race, n (%) | ns | |||
| Caucasian | 14 (63.6) | 15 (62.5) | 11 (57.9) | |
| African American | 5 (22.7) | 8 (33.3) | 5 (26.3) | |
| Asian | 0 (0) | 0 (0) | 1 (5.3) | |
| Other | 1 (4.5) | 1 (4.2) | 2 (10.5) | |
| Unknown | 2 (9.1) | 0 (0) | 0 (0) | |
| Smoking Status | ns | |||
| Current | 7 (31.8) | 7 (29.2) | 6 (31.6) | |
| Former | 5 (22.7) | 2 (8.3) | 3 (15.8) | |
| Never | 9 (40.1) | 13 (54.2) | 10 (52.6) | |
| Unknown | 1 (4.5) | 2 (8.3) | 0 (0) | |
| CLASI-Activity score, mean +/− SEM | 11.5 +/− 2.6 (n=16) | 12.6 +/− 2.3 (n=19) | 18.3 +/− 2.8 (n=18) | ns |
| CLE subtypes, n (%) | ns | |||
| ACLE | 0 (0) | 0 (0) | 2 (10.5) | |
| SCLE | 10 (45.5) | 9 (37.5) | 8 (42.1) | |
| DLE | 11 (50.0) | 15 (62.5) | 9 (47.4) | |
| LET | 2 (9.9) | 0 (0) | 1 (5.3) | |
| Associated SLE, n (%) | ns | |||
| Present | 7 (31.8) | 9 (37.5) | 2 (10.5) | |
| Absent | 15 (68.2) | 15 (62.5) | 17 (89.5)? | |
| Cicatricial alopecia, n (%) | ns | |||
| Present | 5 (22.7) | 12 (50) | 8 (42.1) | |
| Absent | 14 (63.6) | 9 (37.5) | 10 (52.6) | |
| Unknown | 3 (13.6) | 3 (12.5) | 1 (5.3) | |
| Disseminated DLE, n (%) | ns | |||
| Present | 3 (13.6) | 6 (25) | 5 (26.3) | |
| Absent | 19 (86.4) | 18 (75) | 14 (73.7) | |
| Hypertrophic DLE. n (%) | ns | |||
| Present | 1 (4.5) | 2 (8.3) | 1 (5.3) | |
| Absent | 21 (95.5) | 22 (91.7) | 18 (94.7) |