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. Author manuscript; available in PMC: 2023 Jul 15.
Published in final edited form as: Biol Psychiatry. 2021 Sep 27;92(2):127–138. doi: 10.1016/j.biopsych.2021.09.017

Figure 2. Increased NAc Kmt2a expression due to PTE is associated with impaired motivational behavior and dysregulation of genes functionally related to neuronal development and plasticity.

Figure 2.

(A) Changes in the mRNA levels of epigenetic regulators. Red dots: upregulated genes at p<0.05. N=5–6/group, PND62. (B) Kmt2a mRNA expression throughout development and (C) protein level in young adult offspring. (D) PR food SA breakpoint in siRNA-infused animals, 24h post-infusion. N=4–6/group. Data represented as mean ± SEM. *:p <0.05. (E) Gene expression alterations in adult rats with prenatal THC. Blue dots: downregulated genes, red dots: upregulated genes at p<0.05. N=6–10/group, PND62.