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. Author manuscript; available in PMC: 2022 Mar 27.
Published in final edited form as: Xenotransplantation. 2020 Sep 9;28(1):e12642. doi: 10.1111/xen.12642

FIGURE 2.

FIGURE 2

Serum creatinine levels following VT + K XTx and histological and gross findings of the excised kidneys. A, Samples from baboon #14P41. sCre levels following VT + K XTx (top left). Gross finding of hemorrhagic kidney and vascularized thymic grafts at POD 20 (bottom right). HE findings of excised kidney and vascularized thymic graft (middle column). Immunofluorescence pictures of IgM, IgG, C3, C4d, and C5t> (right column). B, Samples from baboon #15P60. sCre levels following VT + K XTx (top left). Gross finding of the excised kidney graft (bottom left). HE findings of excised kidney and vascularized thymic graft (middle column). Immunofluorescence pictures of IgM, IgG and C3 of the excised kidney graft (right column). C, Samples from baboons that did not reject kidneys. sCre levels following VT + K XTx of 15P46 (top left), 14P31 (middle left), and 14P18 (bottom left). HE and IF (IgM, IgG, C3, C4d, and C5b) findings of excised kidneys (middle and right columns). Baboons #15P46 and #14P31 were euthanized due to other causes (see main text). sCre of 14P18 showed increase in sCre from POD 120 due to cortical ischemia associated with increased graft volume. 9GE: GalT-KO/CMAH-KO/B4-KO with hCD46, hCD55, CD201, EPCR, hCD47, HO-1 Tg. 7GE: GalT-KO/CMAH-KO/B4-KO. CD201, EPCR, hCD47, HO-1 (neither hCD46 nor hCD55 Tg)