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. Author manuscript; available in PMC: 2022 Mar 27.
Published in final edited form as: Cell Rep. 2022 Mar 8;38(10):110467. doi: 10.1016/j.celrep.2022.110467

Figure 1. Experimental design for human pituitary cell type identification.

Figure 1.

(A) Schematic of the overall experimental workflow, from procurement of the frozen pituitaries to sn data analysis.

(B) Schematic summarizing sn data integration. For each sample, the snATAC-seq dataset (colored dot UMAP) was integrated with the snRNA-seq dataset (black contours UMAP) to generate an integrated multiomics overlay UMAP identifying cell types. On the UMAP, cell types are color-coded and designated with a two- to three-letter code, as indicated on the bottom key. The female pediatric pituitary sample is represented as an example.

(C) All integrated samples are presented in Figure S1. Schematic of the comparison between sn paired assays (same-sample sn multiomics) (i) and sn multiome assay (same-cell) (ii).

(D) Same-cell sn multiome UMAP from the female pediatric sample (see Table 1).