Table 5. Analysis of factors affecting complaints after treatment changes.

	Increased		Decreased		Unchanged		p
	n	%	n	%	n	%
Continued medications-1*							<0.001
Yes	16	9.0	1	0.6	161	90.4
No	75	75.8	2	2.0	22	22.2
Continued medications-2*							<0.001a
Continued as it was before	16	9.0	1	0.6	161	90.4	<0.001b
Stopped all of the medications	31	79.5	2	5.1	6	15.4	<0.001c
Stopped only biological and synthetic therapy	18	81.8	0	0	4	18.2	1.000d
Decreased or skipped the dose of biological therapy	26	68.4	0	0	12	31.6	1.000e 0.993f
Receiving infusion therapy*							0.024
Yes	26	48.1	0	0	28	51.9
No	65	29.3	3	1.4	154	69.4
* p<0.001, Chi square test, p-values were adjusted using Bonferroni method for pairwise comparisons. pa: Continued as it was before vs. decreased or skipped the dose of biological therapy pb: Continued as it was before vs. stopped only biological and synthetic therapy pc: Continued as it was before vs. stopped all of the medications pd: Stopped only biological and synthetic therapy vs.decreased or skipped the dose of biological therapy pe: Stopped only biological and synthetic therapy vs. stopped all of the medications pf: Stopped all of the medications vs. decreased or skipped the dose of biological therapy