TABLE 2.

Description of the key characteristics of adducts and features networks.

Adducts and features networks’ main characteristics
Nodes	Features, intermediate level annotations (m/z + RT + adduct information)
Edges	Putative relationships between features, such as adducts of a metabolite, in-source fragments of a metabolite, or isotopologues of an adduct
Main Hypothesis	Same as mass difference networks, but with more detailed description using RT separation and characteristic patterns associated to adducts ions formation, ion-source fragmentations, and isotope patterns
Limitations	The mass differences between two features can correspond to a chemical relationship between two features (e.g., isotopologues or adducts), but these features correspond to the same metabolite