FIGURE 5.

Survival analysis of PRS in ROSMAP. The sample was divided into three groups based on 0–33, 33–67, and 67–100% PRS distribution. The 0–33% group had low PRS scores indicating lower predicted risk of developing depression, the 67–100% group had higher PRS scores with higher predicted risk, and the 33–67% group falling in the middle. Survival curves were used to assess effect of higher PRS scores on age of depression onset. (A) Survival curves in the full LOAD sample demonstrated that individuals within the high PRS score group had earlier onsets of depression, meeting significance using the log-rank test (P = 0.019) (B) In the APOEε3 homosygote sample, individuals within higher PRS score groups had eariler depression onset, meeting signficance with the log-rank test (P = 0.036).