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Nobiletin inhibits Keap1/Nrf2/HO-1 axis in melanoma cells. (A–C) The mRNA levels of Keap1, Nrf2, and HO-1 in SK-MEL-28 cells treated with indicate concentration of nobiletin (5, 15, and 45 μM). (D,H) The protein levels of Keap1, total Nrf2, nucleus Nrf2, and HO-1 in SK-MEL-28 cells treated with nobiletin (5, 15, and 45 μM). n = 3, *p < 0.05, **p < 0.01, and ***p < 0.001.
