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. 2022 Mar 8;13:865073. doi: 10.3389/fgene.2022.865073

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Copyright © 2022 Feng, Zhou, Huang, Lin, Zeng, Han, Huang, Liu, Zhu, Yuan and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enhanced expression of GSK3β downregulates of Keap1/Nrf2/HO-1 signaling pathway and significantly increases nobiletin-induced ferroptosis. (A) The mRNA levels of Keap1, Nrf2, and HO-1 in SK-MEL-28 cells with enhanced expression of GSK3β. (B,C) The protein levels of Keap1, total Nrf2, nucleus Nrf2 and HO-1 in SK-MEL-28 cells with enhanced expression of GSK3β. (D) Cell viability of SK-MEL-28 cells with enhanced expression of GSK3β after nobiletin-treatment. (E–I) The levels of MDA, ROS, GSH, and iron in SK-MEL-28 cells with enhanced expression of GSK3β after nobiletin-treatment. n = 3, *p < 0.05, **p < 0.01, and ***p < 0.001.