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. 2022 Mar 8;10:844119. doi: 10.3389/fbioe.2022.844119

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Copyright © 2022 Khan, Fytianos, Blumer, Roux, Gazdhar, Savic, Knudsen, Jonigk, Kuehnel, Mykoniati, Tamm, Geiser and Hostettler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Basal-like cell-CM reduces the Ashcroft score, collagen level, and number of myofibroblasts in bleomycin-injured rat lung. Assessment of lung fibrosis using the Ashcroft scores for grading pulmonary fibrosis 14 days after bleomycin instillation (A). Collagen level as measured by hydroxyproline assay at day 14. (*p ˂ 0.05) (B). Number of myofibroblasts (α-SMA⁺/vimentin⁺/desmin⁻). Stopping gate was set at 30,000 recorded live events at the single cell gate. Dead and doublet cells were excluded from the analysis (C). Number of α-SMA-positive cells producing collagen-1a (D). A total of six groups were used (five rats per group). Group legends: A, control medium; B, fibroblast-CM; C, basal-like cell-CM; D, basal-like cell-CM + PGE2 inhibitor; and E, basal-like cell-CM + PGE2 isotype control (n = 5; error bars: mean ± SEM; *p = 0.05, and ***p = 0.001).