TABLE 4.
Insulin doses, insulin-to-carbohydrate ratio and insulin sensitivity factor for the study participants according to their pubertal status.
| Prepubertal (Tanner stage 1) (n = 40) | Early to mid-pubertal (Tanner stages 2 and 3) (n = 29) | Late-pubertal and postpubertal (Tanner stages 4 and 5) (n = 24) | p-value | |
| TDD (U/kg/day), median (IQR) | 0.91 (0.85 – 0.95) | 0.94 (0.89 – 1.01) | 0.97 (0.91 – 1.04) | 0.004 |
| Basal insulin dose (U/kg/day), median (IQR) | 0.40 (0.35–0.44) | 0.41 (0.38–0.45) | 0.42 (0.37–0.47) | 0.69 |
| Correction dose to TDD (%), mean ± SD | 8.3 ± 2.5 | 8.6 ± 2.2 | 7.6 ± 1.7 | 0.26 |
| Morning ICR (grams/unit of insulin), median (IQR) | 15 (12–15) | 10 (7.5–12) | 6.25 (5.00–7.50) | < 0.001 |
| Afternoon ICR (grams/unit of insulin), median (IQR) | 15 (12–15) | 10 (7.5–12) | 6.25 (6.25–7.50) | < 0.001 |
| Evening ICR (grams/unit of insulin), median (IQR) | 15 (15–18) | 12 (10–15) | 7.5 (6.4–9.4) | < 0.001 |
| Real-life morning ISF (in mg/dL), median (IQR) | 75 (60–80) | 50 (40–60) | 35 (30–40) | < 0.001 |
| Real-life afternoon ISF (in mg/dL), median (IQR) | 75 (63.8–80.0) | 50 (40–60) | 40 (30–40) | < 0.001 |
| Real-life evening ISF (in mg/dL), median (IQR) | 80 (75–90) | 60 (50–75) | 40 (40–50) | < 0.001 |
ICR, insulin-to-carbohydrate ratio; IQR, interquartile range; ISF, insulin sensitivity factor; SD, standard deviation; TDD, total daily insulin dose.