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. 2022 Mar 8;12:799501. doi: 10.3389/fcimb.2022.799501

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Copyright © 2022 Thurman, Ravel, Gajer, Marzinke, Ouattara, Jacot, Peet, Clark and Doncel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–C) Correlation of tenofovir (TFV) vaginal fluid concentration with the relative abundance of Gardnerella vaginalis at months 1, 2, and 3. Green dots represent participants who had Lactobacillus-dominated (LbD) vaginal microbiota at the time of sampling and their individual TFV vaginal fluid concentration and relative abundance of Gardnerella vaginalis. Blue dots represent participants who had diverse anaerobe-dominated (CST IVA/B) vaginal microbiota at the time of sampling and their individual TFV vaginal fluid concentration and relative abundance of Gardnerella vaginalis.