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. 2022 Mar 8;12:799501. doi: 10.3389/fcimb.2022.799501

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Copyright © 2022 Thurman, Ravel, Gajer, Marzinke, Ouattara, Jacot, Peet, Clark and Doncel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cumulative (CUMU) p24 antigen production from cervicovaginal (CV) tissue biopsies obtained from all participants at baseline and from participants using the placebo IVR (BL). CUMU p24 antigen production from CV tissue biopsies obtained from participants using the TFV/LNG IVR at end of treatment (EOT). Red dots represent participant data from individuals with diverse anaerobic CST IVA/B microbiota at sampling. Blue dots represent participant data from individuals with Lactobacillus-dominated (LbD) microbiota at sampling. p values > 0.05 for change in p24 antigen production from tissues at EOT compared to BL.