Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 8;10:823933. doi: 10.3389/fbioe.2022.823933

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhou, Wang, Yang, Wang, Zhao, Zhou, Fu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

DSF significantly reduced fibroblast activation and proliferation after BMDM exosome treatment. NIH/3T3 fibroblasts were cultured and treated with macrophage-derived exosomes. Cells were pretreated with DSF (5 μM) or DMSO (0.01%) for 2 h. (A,B) Western blot (A) and quantitative (B) analyses of FN, Col-I, and α-SMA in fibroblast from control, exosomes, and exosomes in the presence of DSF. (C) Quantitative analysis of EdU incorporation in fibroblast from control, exosomes, and exosomes in the presence of DSF. (D,E) FACS (D) and quantitative (E) analysis of cell cycle in fibroblast from control, exosomes, and exosomes in the presence of DSF. (F,G) The picture (F) and quantitative analysis (G) of the cell migration in fibroblast from control, exosomes, and exosomes in the presence of DSF. Scale bar = 20 μm. (H,I) The picture (H) and quantitative analysis (I) of the cell wound scratch assay in fibroblast from control, exosomes, and exosomes in the presence of DSF. Scale bar = 20 μm. Data are presented as the mean ± SEM (n = 3) (B,C,E,G,I). *p < 0.05.