TABLE 1.

NLRP3 inhibitors.

Inhibitor	Inhibition mechanism	Specificity	Inhibition of priming	Clinical status	Refs.
MCC950	Binds Walker B motif; NACHT ATPase inhibitor	NLRP3	No	Phase 2	Zahid et al. (2019)
CY-09	Binds Walker A motif; NACHT ATPase inhibitor	NLRP3	No	—	Jiang et al. (2017)
Glibenclamide	Inhibits ATP-sensitive K+ channels	NLRP3	No	Phase 4	Dwivedi and Jena, (2020)
Parthenolide	NACHT ATPase inhibitor and caspase-1 inhibitor	NLRP3	Yes	—	Bahabadi et al. (2017)
		AIM2
		NLRC4
		NLRP1
Bay11-7082	NACHT ATPase inhibitor	NLRP3	Yes	—	Jiang et al. (2017), Yongsheng Yu et al. (2019)
		NLRC4