FIGURE 1.

Dysmorphic features in the CZS. Dysmorphic physical features characteristic of the CZS. One year old boy with craniofacial disproportion, and marked reduction of the volume of the cranial vault, including lateral depressions of the frontal bone (A) and an occipital prominence (B). These severe features have remained visible since birth. Skin redundance in frontal and glabellar area with vertical folds in a 3 month old (C) and multiple folds across the scalp, called cutis rugata in a 1 month old (D). Generalized contractures of large and small joints (E). Contractures of all fingers (F). Abnormal single transverse palmar crease (G). Club foot (H). Deep dimple at the knee (I).