Table 1.

LncRNAs in septic AKI.

AKI	lncRNA	Expression	Regulation network	Function	Reference
Septic AKI	MALAT1	up	miR-146a/NF-κB	Promote cytokine creation and immune response	Ding et al. (2018)
	NEAT1	up	miR-22-3p/NF-κB	Promote cell apoptosis	Feng et al. (2020)
			let-7b-5p/TRAF6	Promote inflammation	Gao et al. (2020b)
			miR-93-5p/TXNIP	Promote apoptosis, inflammation, and oxidative stress	Yang et al. (2021b)
			miR-27a-3p/TAB3	Promote cell apoptosis	Wang et al. (2020a)
			miR-125a-5P/TRAF6/TAK1	Modulate macrophage polarization	Wang and Guo (2020)
	PVT1	up	miR-17-5p/ NF-κB	Promote cell apoptosis	Yuan et al. (2021b)
			miR-20a-5p/NLRP3	Promote cell pyroptosis and inflammatory factors creation	Deng et al. (2021b)
	DLX6-AS1	up	miR-223-3p/NLRP3	Improve cytotoxicity	Tan et al. (2020)
	MEG3	up	miR-21/PDCD4	Promote cell apoptosis	Yang et al. (2018)
			miR-18a-3p/GSDMD	Promote pyroptosis	Deng et al. (2021a)
	TapSAKI	up	miR-22/PTEN/TLR4/NF-κB	Promote cell apoptosis and inflammation response	Shen et al. (2019)
			miR-205/IRF3	Enhance cytotoxicity	Han et al. (2021b)
	SNHG14	up	miR-93/IRAK4/NF-κB	Accelerate cellular injury	Shi et al. (2021)
			miR-495-3p/HIPK1	Inhibit cell proliferation and autophagy	Yang et al. (2021a)
	SNHG5	up	miR-374a-3p/TLR4/NF-κB	Promote cell apoptosis	Wang et al. (2021)
	MIAT	up	miR-29a	Promote cell apoptosis	Zhang et al. (2019)
	ANRIL	up	miR-199a/TLR4/NF-kB	Promote cell apoptosis	Zhu et al. (2020b)
	TCONS_00016233	up	miR-22-3p/AIFM1	Promote LPS-induced HK-2 cell apoptosis and the expression of IL-1b and TNF-a	Zhang et al. (2020b)
	SIKIAT1	up	miR-96-3p	Promote cell apoptosis	Lu et al. (2020b)
	RMRP	up	miR-206/DPX5	Promote cell apoptosis	Zhang et al. (2021)
	NKILA	up	miR-140-5p/CLDMA	Promote cell apoptosis	Han et al. (2021a)
	XIST	up	miR-15a-5p/ CUL3	Enhance podocyte cell apoptosis	Xu et al. (2019)
	GAS5	down	PI3K/AKT	Promotes podocyte injury	Fang et al. (2018)
	PlncRNA-1	down	-	Promote cell proliferation, inhibit apoptosis and autophagy	Fu et al. (2018)
	DANCR	down	miR-214/KLF6	Suppress cell apoptosis and cytokine creation	Zhao et al. (2020)
	lncRNA6406	down	miR-687/PTEN	Alleviate inflammation, oxidative stress, and inhibit apoptosis	Liu et al. (2020)
	HOXA-AS2	down	miR-106b-5p/Wnt/β-catenin/ NF-κB	Inhibit the inflammation	Wu et al. (2020b)
	LINC00261	down	miR-654-5p/SOCS3/NF-κB	Improve cell viability, suppress the apoptosis, and reduced the generation of inflammation cytokines	Li et al. (2021c)
	CASC2	down	miR-155/NF-κB	Inhibit inflammation factors creation, cell apoptosis and oxidative stress	Wang et al. (2020d)
			miR-545-3p/PPARA	Facilities cell viability and restrain cell apoptosis migration EMT and oxidative stress	Hu et al. (2021)
	CCAT-1	down	miR-155/SIRT1	Attenuate inflammatory response and apoptosis	Lu et al. (2020a)
	NONRATG019935.2	down	P53	Suppress the apoptosis	Ding et al. (2021)
	CRNDE	up	TLR3/NF-κB	Promote kidney injury	Sun et al. (2019)
			miR-146a /TLR4/NF-κB	Accelerate LPS-induced inflammation and apoptosis	Wu et al. (2020a)
		down	miR-181a-5p	Accelerate LPS-induced inflammation and apoptosis	Wang et al. (2020c)
	HOTAIR	up	miR-34a/Bcl-2	Inhibit the apoptosis of kidney tissues	Jiang et al. (2019b)
			miR-22/HMGB1	Promote HK-2 cell apoptosis	Shen et al. (2018)