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. 2022 Mar 8;13:849403. doi: 10.3389/fphys.2022.849403

Table 2.

LncRNAs in I/R-induced AKI.

AKI lncRNA Expression Regulation network Function Reference
I/R-AKI MALAT1 up NF-κB Inhibit the hypoxia-induced inflammatory response Kölling et al. (2018)
PRINS up RANTES Promote inflammation Yu et al. (2016)
SNHG14 up miR-124-3p/ MMP2 Promote inflammation and oxidative stress Xue et al. (2021)
EGOT down HuR-ATG7/16 L1 Promote the hypoxia-induced autophagy Wang et al. (2020b)
XIST up miR-124-3p/ITGB1 Promote apoptosis and inflammation Chen et al. (2020)
miR-142-5p/ PDCD4 Promote CoCl2-induced cellular apoptosis Tang et al. (2020)
NEAT1 up miR-27a-3p Promote CoCl2-induced cellular apoptosis Jiang et al. (2019a)
GAS5 up miR-21 Promote cell apoptosis Geng et al. (2020)
LINC00520 up miR-27b-3p/OSMR Promote cell apoptosis Tian et al. (2019)
LINC00963 up miR-128-3p/ JAK2/STAT1 Reduce G1 arrest and apoptosis Xie et al. (2020)
MEG3 up miR-145-5p /Wnt/β-catenin Activate mitophagy and induce apoptosis Liu et al. (2021)
LINC00052 down miR-532-3p/ Wnt/β-catenin Decrease hypoxia-induced ROS and MDA accumulation Li et al. (2020)
H19 up miR-130a/BCL2L11 Augment cell apoptosis Yuan et al. (2021a)
miR-30a-5p Reduce cell apoptosis and inflammation Haddad et al. (2021)
TUG1 down miR-494-3p/ E-cadherin Alleviate cell apoptosis Chen et al. (2021b)