Table 2.
AKI | lncRNA | Expression | Regulation network | Function | Reference |
---|---|---|---|---|---|
I/R-AKI | MALAT1 | up | NF-κB | Inhibit the hypoxia-induced inflammatory response | Kölling et al. (2018) |
PRINS | up | RANTES | Promote inflammation | Yu et al. (2016) | |
SNHG14 | up | miR-124-3p/ MMP2 | Promote inflammation and oxidative stress | Xue et al. (2021) | |
EGOT | down | HuR-ATG7/16 L1 | Promote the hypoxia-induced autophagy | Wang et al. (2020b) | |
XIST | up | miR-124-3p/ITGB1 | Promote apoptosis and inflammation | Chen et al. (2020) | |
miR-142-5p/ PDCD4 | Promote CoCl2-induced cellular apoptosis | Tang et al. (2020) | |||
NEAT1 | up | miR-27a-3p | Promote CoCl2-induced cellular apoptosis | Jiang et al. (2019a) | |
GAS5 | up | miR-21 | Promote cell apoptosis | Geng et al. (2020) | |
LINC00520 | up | miR-27b-3p/OSMR | Promote cell apoptosis | Tian et al. (2019) | |
LINC00963 | up | miR-128-3p/ JAK2/STAT1 | Reduce G1 arrest and apoptosis | Xie et al. (2020) | |
MEG3 | up | miR-145-5p /Wnt/β-catenin | Activate mitophagy and induce apoptosis | Liu et al. (2021) | |
LINC00052 | down | miR-532-3p/ Wnt/β-catenin | Decrease hypoxia-induced ROS and MDA accumulation | Li et al. (2020) | |
H19 | up | miR-130a/BCL2L11 | Augment cell apoptosis | Yuan et al. (2021a) | |
miR-30a-5p | Reduce cell apoptosis and inflammation | Haddad et al. (2021) | |||
TUG1 | down | miR-494-3p/ E-cadherin | Alleviate cell apoptosis | Chen et al. (2021b) |