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. 2022 Mar 8;13:836789. doi: 10.3389/fphys.2022.836789

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Copyright © 2022 Maer, Rusinova, Providence, Ingólfsson, Collingwood, Lundbæk and Andersen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of changes in bilayer composition and head group interactions on AgA(15) and gA^–(13) channel lifetimes; results for AgA(15) in blue, results for gA^–(13) in red. (A) Effects of varying the DOPE:DOPC molar ratio. The superscript “ref” denotes the value in DOPC bilayers. Experimental conditions as in Figure 7. (B) Effects of pH on the channel lifetimes in DOPS bilayers. The superscript “ref” denotes the value at pH 7. 0.1 M NaCl. (C) Effects of [Ca²⁺] on the channel lifetimes in DOPS bilayers. The superscript “ref” denotes the value in the nominal absence of Ca²⁺. 0.1 M NaCl, pH 7. In all panels: mean ± SD, n ≥ 3.