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. 2022 Mar 8;13:836789. doi: 10.3389/fphys.2022.836789

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Copyright © 2022 Maer, Rusinova, Providence, Ingólfsson, Collingwood, Lundbæk and Andersen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of changes in bilayer composition on AgA(15) and gA^–(13) channel function. (A) Current transition amplitude histograms obtained in (from top to bottom): DOPC/n-decane, DoPC/n-decane and DLoPC/n-decane bilayers. The lower amplitude peaks, highlighted in red, denote gA^–(13) channels; the higher amplitude peaks, highlighted in blue, the AgA(15) channels. (B) The corresponding normalized single-channel duration histograms. Results from single experiments fitted by single exponential distributions (the colors have same significance as in A). The lifetime results are summarized in Table 3. 1 M NaCl, pH 7, 200 mV, 500 Hz.