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Proposed tobramycin resistance mechanisms in 56 P. aeruginosa isolates
| Resistance mechanism | No. of isolates | Tobramycin MIC (μg/ml) |
|---|---|---|
| Impermeabilitya | 49 | 16–>512 |
| Impermeability + AAC (6′)-Ib | 2 | 32, 512 |
| ANT (2")-Ia | 3 | 8, 16, 32 |
| AAC (6′)-Ib | 2 | 16, 16 |
Negative for modifying enzymes by hybridization.
