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. 2022 Mar 8;10:868063. doi: 10.3389/fchem.2022.868063

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Copyright © 2022 Zhou, Niu, Huang, Chen, Yu, Cao, Pei and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biosafety analysis of ApoE^−/- mice after different treatment at day 30. (A) The body weight of ApoE^−/−mice during various treatments. (B) The lipid profile of ApoE^−/- mice after different treatment. (C–F) The biochemical assays of hepatic and kidney functions. ALT, alanine aminotransferase; AST, aspartate aminotransferase; URN, blood urea nitrogen; and CRE, creatinine. n = 5, mean ± SD.