TABLE 3.
Activities of resolved quinazolinonesa
| Compound | IC90 (nM)
|
Enzyme IC50 (nM) | |
|---|---|---|---|
| K103N mutant | Wild type | ||
| 14 | 9 | 1.6 | 15 ± 8 |
| DPC 961 | 10 ± 3.2 | 2.0 ± 0.7 | 31 ± 8 |
| DPC 963 | 11 ± 4.8 | 1.3 ± 0.6 | 18 ± 5 |
a
Wild-type virus was assessed in MT-2 cells by oligonucleotide capture of viral RNA after 3 days of infection. K103N mutant variant was used to infect MT-4 cells, and viral p24 antigen levels were measured after 3 days. The data represent the means ± standard deviations for two to six independent determinations.