Immunofluorescence staining analysis of Pre-healing factor. (A) On day 7, immunofluorescence staining of TNF-α, IL-10, AGEs, MMP-9, and VEGF was performed on the wounds of different groups, scale bar: 20 . (B, C, D, E, F) The relative quantitative analysis of the expression of TNF-α, IL-10, AGEs, MMP-9, and VEGF data were normalised against the results of the gauze group at day 7, and the data of the gauze group was defined as 100%. Note: Hydrogel Ⅱ: the CBP/GMs hydrogel; Hydrogel Ⅲ: the CBP/GMs@INS hydrogel; Hydrogel Ⅳ: the CBP/GMs@Cel&INS hydrogel.