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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Neuropharmacology. 2021 Dec 10;205:108920. doi: 10.1016/j.neuropharm.2021.108920

Figure 1. Multisystem impact of tissue-specific insulin receptor deletion.

Figure 1.

A) Tissue-specific effects of constitutive deletion of insulin receptor (IR) in pancreatic beta-cells, muscle, liver, or white adipose tissue. Dashed lines represent circulating factors that regulate cognition and are disrupted in tissue-specific IR knockouts. B) Organism-level metabolic outcomes following selective deletion of IR in peripheral metabolic organs. Abbreviations: HFD, high-fat diet.