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. 2022 Mar 14;35:10312. doi: 10.3389/ti.2022.10312

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Copyright © 2022 Verstraeten and Jochmans.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic overview illustrating metabolic liver zonation with reference to glucose and ammonia metabolism. Blood entering the liver lobule in vivo through hepatic artery (HA) and portal vein (PV) branches is rich in hormones, nutrients and oxygen. Periportal (zone 1) metabolic processes will include those requiring such conditions, while perivenous (zone 3) hepatocytes may preferentially include those metabolic processes that are less dependent on high levels of oxygen, for example, or those requiring products made in the periportal hepatocytes, such as urea. Reproduced from (84) with permission under Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0).