| Methods |
Double‐blind; computer randomisation |
| Participants |
160 volunteer travellers (80 men) flying eastwards from America to Switzerland across 6 to 9 time zones after a stay of at least 7 days in America. 137 completed the study. |
| Interventions |
Four groups: a) melatonin 5mg, b) zolpidem 10mg, c) both, or d) placebo, using the double dummy technique. The medication was taken between 5 and 9 pm local time on the day of the flight and then for 4 days at bedtime ['post'] |
| Outcomes |
Sleep quality, profile of mood states, symptoms, wrist activity monitoring (n=80), subjective rating of jet lag, and of efficacy of the medication. Compliance was assessed electronically (MEMS) and by questionnaire. 23 participants who missed one or more doses were excluded from the analysis. Symptoms were noted |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
